Which People were Involved in the Study?
The research used the AMORIS cohort. AMORIS is a population-based resource built from clinical laboratory testing in Stockholm County. It includes more than 800,000 people, but this study focused on 44,636 participants born between 1893 and 1920 who had blood tests between 1985 and 1996. Everyone was followed from the first test until death, or until the end of 2020. During follow-up, 1,224 people reached their 100th birthday. About 85% of the centenarians were women, which reflects broader survival patterns in Sweden at that time. The team linked the lab data to several national registers using Swedish personal identification numbers. That allowed accurate tracking of diseases and deaths. The analysis used descriptive statistics, logistic regression, and clustering.
Those methods helped compare distributions, estimate odds, and see whether centenarians formed distinct lab profiles. The authors note that “half of the participants were followed for more than 10 years,” which gives room for meaningful patterns to show up. They also adjusted their models for the Charlson Comorbidity Index, which summarizes serious health conditions from hospital records. This adjustment helps separate the lab signals from known disease burdens. The overall design is a strength. It reduces recall bias and uses consistent lab methods on fresh samples. The Swedish registers are internationally respected for completeness and quality control. However, not every lifestyle variable was available, and some desirable immune markers were missing.
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